Evolutionary genomics: Codon volatility does not detect selection

@article{Chen2005EvolutionaryGC,
  title={Evolutionary genomics: Codon volatility does not detect selection},
  author={Yin Chen and J J Emerson and Todd M. Martin},
  journal={Nature},
  year={2005},
  volume={433},
  pages={E6-E7}
}
Arising from: J. B. Plotkin, J. Dushoff & H. B. Fraser 428, 942–945 (2004); see also communication from Hahn et al.; Nielsen et al.; Plotkin et al. replyPlotkin et al. introduce a method to detect selection that is based on an index called codon volatility and that uses only the sequence of a single genome, claiming that this method is applicable to a large range of sequenced organisms. Volatility for a given codon is the ratio of non-synonymous codons to all sense codons accessible by one… CONTINUE READING

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