Evolutionary genetic dissection of human interferons

  title={Evolutionary genetic dissection of human interferons},
  author={J{\'e}r{\'e}my Manry and Guillaume Laval and Etienne Patin and Simona Fornarino and Yuval Itan and Matteo Fumagalli and Manuela Sironi and Magali Tichit and Christiane Bouchier and J. Hugo P{\'e}rez Casanova and Luis B Barreiro and Llu{\'i}s Quintana-Murci},
  booktitle={The Journal of experimental medicine},
Interferons (IFNs) are cytokines that play a key role in innate and adaptive immune responses. Despite the large number of immunological studies of these molecules, the relative contributions of the numerous IFNs to human survival remain largely unknown. Here, we evaluated the extent to which natural selection has targeted the human IFNs and their receptors, to provide insight into the mechanisms that govern host defense in the natural setting. We found that some IFN-α subtypes, such as IFN-α6… CONTINUE READING
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