Evolutionary fates and origins of U12-type introns.

  title={Evolutionary fates and origins of U12-type introns.},
  author={Christopher B. Burge and Richard A. Padgett and Phillip A. Sharp},
  journal={Molecular cell},
  volume={2 6},
U2-type and U12-type introns are spliced by distinct spliceosomes in eukaryotic nuclei. A classification method was devised to distinguish these two types of introns based on splice site sequence properties and was used to identify 56 different genes containing U12-type introns in available genomic sequences. U12-type introns occur with consistently low frequency in diverse eukaryotic taxa but have almost certainly been lost from C. elegans. Comparisons with available homologous sequences… CONTINUE READING
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