Evolutionary expansion of a regulatory network by counter-silencing

@inproceedings{Will2014EvolutionaryEO,
  title={Evolutionary expansion of a regulatory network by counter-silencing},
  author={William Ryan Will and Denise H. Bale and Philip John Reid and Stephen James Libby and Ferric C. Fang},
  booktitle={Nature communications},
  year={2014}
}
Horizontal gene transfer plays a major role in bacterial evolution. Successful acquisition of new genes requires their incorporation into existing regulatory networks. This study compares the regulation of conserved genes in the PhoPQ regulon of Salmonella enterica serovar Typhimurium with that of PhoPQ-regulated horizontally acquired genes, which are silenced by the histone-like protein H-NS. We demonstrate that PhoP upregulates conserved and horizontally acquired genes by distinct mechanisms… CONTINUE READING

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