Evolutionary dynamics of the Warburg effect: glycolysis as a collective action problem among cancer cells.

@article{Archetti2014EvolutionaryDO,
  title={Evolutionary dynamics of the Warburg effect: glycolysis as a collective action problem among cancer cells.},
  author={Marco Archetti},
  journal={Journal of theoretical biology},
  year={2014},
  volume={341},
  pages={1-8}
}
The upregulation of glycolysis in cancer cells (the "Warburg effect") is common and has implications for prognosis and treatment. As it is energetically inefficient under adequate oxygen supply, its adaptive value for a tumor remains unclear. It has been suggested that the acidity produced by glycolysis is beneficial for cancer cells because it promotes proliferation against normal cells. Current models of this acid-mediated tumor invasion hypothesis, however, do not account for increased… CONTINUE READING

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