Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes.

@article{Waterhouse2007EvolutionaryDO,
  title={Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes.},
  author={Robert M. Waterhouse and Evgenia V. Kriventseva and Stephan Meister and Zhiyong Xi and Kanwal S. Alvarez and Lyric C. Bartholomay and Carolina Barillas-Mury and Guowu Bian and St{\'e}phanie A. Blandin and Bruce M. Christensen and Yuemei Dong and Haobo Jiang and Michael R. Kanost and Anastasios C Koutsos and Elena A Levashina and Jianyong Li and Petros Ligoxygakis and Robert M. MacCallum and George F. Mayhew and A Mendes and Kristin Michel and Mike A Osta and Susan M. Paskewitz and Sang Woon Shin and Dina Vlachou and Lihui Wang and Weiqi Wei and Liangbiao Zheng and Zhen Zou and David W. Severson and Alexander S. Raikhel and Fotis C. Kafatos and George Dimopoulos and Evgeny M. Zdobnov and George K. Christophides},
  journal={Science},
  year={2007},
  volume={316 5832},
  pages={1738-43}
}
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated… CONTINUE READING
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