Evolutionary dynamics of feedback escape and the development of stem-cell-driven cancers.

@article{RodriguezBrenes2011EvolutionaryDO,
  title={Evolutionary dynamics of feedback escape and the development of stem-cell-driven cancers.},
  author={Ignacio A. Rodriguez-Brenes and Natalia L. Komarova and Dominik Wodarz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 47},
  pages={18983-8}
}
Cancers are thought to arise in tissue stem cells, and similar to healthy tissue, are thought to be maintained by a small population of tumor stem or initiating cells, whereas the majority of tumor cells are more differentiated with limited replicative potential. Healthy tissue homeostasis is achieved by feedback loops, and particular importance has been attached to signals secreted from differentiated cells that inhibit stem-cell division and stem-cell self-renewal, as documented in the… CONTINUE READING