Evolutionary dynamics of complex networks of HIV drug-resistant strains: the case of San Francisco.

  title={Evolutionary dynamics of complex networks of HIV drug-resistant strains: the case of San Francisco.},
  author={Robert J. Smith and Justin T Okano and James S. Kahn and Erin N. Bodine and Sally M. Blower},
  volume={327 5966},
Over the past two decades, HIV resistance to antiretroviral drugs (ARVs) has risen to high levels in the wealthier countries of the world, which are able to afford widespread treatment. We have gained insights into the evolution and transmission dynamics of ARV resistance by designing a biologically complex multistrain network model. With this model, we traced the evolutionary history of ARV resistance in San Francisco and predict its future dynamics. By using classification and regression… CONTINUE READING

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