Evolutionary dynamics of cancer in response to targeted combination therapy

@inproceedings{Bozic2013EvolutionaryDO,
  title={Evolutionary dynamics of cancer in response to targeted combination therapy},
  author={Ivana Bozic and Johannes G. Reiter and Benjamin Allen and Tibor Antal and Krishnendu Chatterjee and Preya Shah and Yo Sup Moon and Amin Yaqubie and Nicole J. Kelly and Dung T Le and Evan J. Lipson and Paul B Chapman and Luis A Diaz and Bert Vogelstein and Martin A. Nowak},
  booktitle={eLife},
  year={2013}
}
In solid tumors, targeted treatments can lead to dramatic regressions, but responses are often short-lived because resistant cancer cells arise. The major strategy proposed for overcoming resistance is combination therapy. We present a mathematical model describing the evolutionary dynamics of lesions in response to treatment. We first studied 20 melanoma patients receiving vemurafenib. We then applied our model to an independent set of pancreatic, colorectal, and melanoma cancer patients with… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 230 CITATIONS

FILTER CITATIONS BY YEAR

2013
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

  • Averaged 45 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES

Similar Papers

Loading similar papers…