Evolutionary dynamics of adult stem cells: comparison of random and immortal-strand segregation mechanisms.

Abstract

This paper develops a point-mutation model describing the evolutionary dynamics of a population of adult stem cells. Such a model may prove useful for quantitative studies of tissue aging and the emergence of cancer. We consider two modes of chromosome segregation: (1) random segregation, where the daughter chromosomes of a given parent chromosome segregate… (More)
DOI: 10.1103/PhysRevE.71.041914

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Citations per Year

Citation Velocity: 7

Averaging 7 citations per year over the last 3 years.

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