Evolutionary diversification of TTX-resistant sodium channels in a predator–prey interaction

@article{Geffeney2005EvolutionaryDO,
  title={Evolutionary diversification of TTX-resistant sodium channels in a predator–prey interaction},
  author={S. Geffeney and E. Fujimoto and E. Brodie and P. Ruben},
  journal={Nature},
  year={2005},
  volume={434},
  pages={759-763}
}
Understanding the molecular genetic basis of adaptations provides incomparable insight into the genetic mechanisms by which evolutionary diversification takes place. Whether the evolution of common traits in different lineages proceeds by similar or unique mutations, and the degree to which phenotypic evolution is controlled by changes in gene regulation as opposed to gene function, are fundamental questions in evolutionary biology that require such an understanding of genetic mechanisms. Here… Expand

Figures, Tables, and Topics from this paper

Convergent Evolution of Tetrodotoxin-Resistant Sodium Channels in Predators and Prey.
TLDR
Broad patterns of convergence at the level of amino acid changes in NaV channels of animals that evolved TTX resistance are reviewed and comparisons to known TTX-resistant channels are made that did not evolve under the selective pressures imposed by TTX. Expand
Gene Conversion Facilitates the Adaptive Evolution of Self-Resistance in Highly Toxic Newts
TLDR
This work reconstructs the origins of TTX self-resistance by sequencing the entire Nav gene family in newts and related salamanders and demonstrates that gene conversion can accelerate the coordinated evolution of gene families in response to a common selection pressure. Expand
Gene Conversion Facilitates the Adaptive Evolution of Self-Resistance in Highly Toxic Newts.
TLDR
This work reconstructs the origins of TTX self-resistance by sequencing the entire Nav gene family in newts and related salamanders and demonstrates that gene conversion can accelerate the coordinated evolution of gene families in response to a common selection pressure. Expand
Historical Contingency in a Multigene Family Facilitates Adaptive Evolution of Toxin Resistance
TLDR
The results show that adaptive protein evolution may be contingent upon enabling substitutions elsewhere in the genome, in this case, in paralogs of the same gene family. Expand
Predictably Convergent Evolution of Sodium Channels in the Arms Race between Predators and Prey
Evolution typically arrives at convergent phenotypic solutions to common challenges of natural selection. However, diverse molecular and physiological mechanisms may generate phenotypes that appearExpand
Predictably Convergent Evolution of Sodium Channels in the Arms Race between Predators and Prey.
TLDR
Trade-offs between the fundamental role of NaV1 proteins in selective permeability of Na+ and their ability to resist binding by TTX generate a highly constrained adaptive landscape at the level of the protein. Expand
Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes
TLDR
It is demonstrated that constraints resulting from functional tradeoffs between ion channel function and toxin resistance led to predictable patterns of evolutionary convergence at the molecular level, suggesting that natural selection may be frequently constrained to produce similar genetic outcomes even when operating on independent lineages. Expand
Toxin-resistant sodium channels: parallel adaptive evolution across a complete gene family.
TLDR
This study shows how 4 taxonomically diverse species of pufferfishes each evolved resistance to the guanidinium toxins tetrodotoxin and saxitoxin via parallel amino acid replacements across all 8 sodium channels present in teleost fish genomes. Expand
Convergent Substitutions in a Sodium Channel Suggest Multiple Origins of Toxin Resistance in Poison Frogs.
TLDR
This study is the first to demonstrate the genetic basis of autoresistance in frogs with alkaloid defenses, and predicts that poison frogs are somewhat resistant to these compounds because they have six types of amino acid replacements in the Nav1.4 inner pore. Expand
Genetic architecture of a feeding adaptation: garter snake (Thamnophis) resistance to tetrodotoxin bearing prey
TLDR
The simple genetic architecture of TTX resistance in garter snakes may significantly impact the dynamics of phenotypic coevolution, and the contribution of Nav1.4 alleles is evaluated to suggest that this locus is a major effect locus. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 52 REFERENCES
Mechanisms of Adaptation in a Predator-Prey Arms Race: TTX-Resistant Sodium Channels
TLDR
A physiological mechanism, the expression of TTX-resistant sodium channels in skeletal muscle, is identified, responsible for adaptive diversification in whole-animal resistance to tetrodotoxin in Thamnophis sirtalis. Expand
PERSPECTIVE: EVOLUTIONARY DEVELOPMENTAL BIOLOGY AND THE PROBLEM OF VARIATION
  • D. Stern
  • Biology, Medicine
  • Evolution; international journal of organic evolution
  • 2000
TLDR
This approach will assist in the task of identifying the specific mutations generating phenotypic variation and elucidating how they alter gene function, which will provide the current missing link between molecular and phenotypesic variation in natural populations. Expand
The genetics and genomics of insecticide resistance.
TLDR
The impact of Drosophila genetics on the field of insect resistance and the current and future impact of genomics is reviewed and three fundamental questions in the evolution of resistance are addressed. Expand
Patterns of evolutionary rate variation among genes of the anthocyanin biosynthetic pathway.
TLDR
It is reported here that upstream genes in the anthocyanin pathway have evolved substantially more slowly than downstream genes and it is suggested that this difference in evolutionary rates may be explained by upstream genes being more constrained because they participate in several different biochemical pathways. Expand
Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.
TLDR
A revised model of TTX and STX binding in the Na+ channel outer vestibule is proposed in which the toxins have similar interactions at the selectivity filter, TTX has a stronger interaction with Tyr401, andSTX interacts more strongly with the more extracellular residues. Expand
Different genes underlie adaptive melanism in different populations of rock pocket mice
TLDR
Results indicate that adaptive melanism has arisen at least twice in C. intermedius and that these similar phenotypic changes have a different genetic basis. Expand
Parallel Evolution and Inheritance of Quantitative Traits
TLDR
It is suggested that influence of shared genetic biases should be detectable by the disproportionate use of the same genes in independent instances of parallel phenotypic evolution, and shown how progress can be made through simple tests of parallel inheritance of genetic differences: similar additive, dominance, and epistasis components in analysis of line means and similar effective numbers of loci. Expand
THE EVOLUTIONARY RESPONSE OF PREDATORS TO DANGEROUS PREY: HOTSPOTS AND COLDSPOTS IN THE GEOGRAPHIC MOSAIC OF COEVOLUTION BETWEEN GARTER SNAKES AND NEWTS
TLDR
Some predicted results of this geographic mosaic of coevolution include maladapted or mismatched phenotypes, maintenance of high levels of polymorphism, and prevention of stable equilibrium trait combinations. Expand
THE EVOLUTIONARY RESPONSE OF PREDATORS TO DANGEROUS PREY: HOTSPOTS AND COLDSPOTS IN THE GEOGRAPHIC MOSAIC OF COEVOLUTION BETWEEN GARTER SNAKES AND NEWTS
TLDR
The geographic pattern of genetically determined TTX resistance in the garter snake Thamnophis sirtalis over much of the range of its ecological interaction with toxic newts of genus Taricha is investigated, providing dramatic evidence that geographic structure is an important component in coevolutionary interactions between predators and prey. Expand
Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II
TLDR
The SS2 and adjacent regions of the 4 internal repeats of sodium channel II were subjected to single mutations involving, mainly, charged amino acid residues, showing that mutations involving 2 clusters of predominantly negatively charged residues strongly reduce toxin sensitivity, whereas mutations of adjacent residues exert much smaller or no effects. Expand
...
1
2
3
4
5
...