Evolutionary diversification of DNA methyltransferases in eukaryotic genomes.

  title={Evolutionary diversification of DNA methyltransferases in eukaryotic genomes.},
  author={Lo{\"i}c Ponger and Wen-Hsiung Li},
  journal={Molecular biology and evolution},
  volume={22 4},
In eukaryotes, C5-cytosine methylation is a common mechanism associated with a variety of functions such as gene regulation or control of genomic stability. Different subfamilies of eukaryotic methyltransferases (MTases) have been identified, mainly in metazoa, plants, and fungi. In this paper, we used hidden Markov models to detect MTases in completed or almost completed eukaryotic genomes, including different species of Protozoa. A phylogenetic analysis of MTases enabled us to define six… CONTINUE READING

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