Evolutionary divergence of the necroptosis effector MLKL

  title={Evolutionary divergence of the necroptosis effector MLKL},
  author={Maria C. Tanzer and I Matti and Joanne M. Hildebrand and Samuel N Young and Ahmad Wardak and Anne Tripaydonis and Emma J. Petrie and Alison L Mildenhall and David L. Vaux and James Edward Vince and Peter E. Czabotar and John Silke and James M Murphy},
  journal={Cell Death and Differentiation},
The pseudokinase, MLKL (mixed-lineage kinase domain-like), is the most terminal obligatory component of the necroptosis cell death pathway known. Phosphorylation of the MLKL pseudokinase domain by the protein kinase, receptor interacting protein kinase-3 (RIPK3), is known to be the key step in MLKL activation. This phosphorylation event is believed to trigger a molecular switch, leading to exposure of the N-terminal four-helix bundle (4HB) domain of MLKL, its oligomerization, membrane… CONTINUE READING
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