Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering

@inproceedings{Kuo2010EvolutionaryDI,
  title={Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering},
  author={Dwight Kuo and Kai Leng Tan and Guy E. Zinman and Timothy Ravasi and Ziv Bar-Joseph and Trey Ideker},
  booktitle={Genome Biology},
  year={2010}
}
Fungal infections are an emerging health risk, especially those involving yeast that are resistant to antifungal agents. To understand the range of mechanisms by which yeasts can respond to anti-fungals, we compared gene expression patterns across three evolutionarily distant species - Saccharomyces cerevisiae, Candida glabrata and Kluyveromyces lactis - over time following fluconazole exposure. Conserved and diverged expression patterns were identified using a novel soft clustering algorithm… CONTINUE READING
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