Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1

@article{Hansen2006EvolutionaryconservedTH,
  title={Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1},
  author={Klavs R. Hansen and Pablo Tejero Ibarra and Genevi{\`e}ve Thon},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={78 - 88}
}
In Schizosaccharomyces pombe the RNAi machinery and proteins mediating heterochromatin formation regulate the transcription of non-coding centromeric repeats. These repeats share a high sequence similarity with telomere-linked helicase (tlh) genes, implying an ancestral relationship between the two types of elements and suggesting that transcription of the tlh genes might be regulated by the same factors as centromeric repeats. Indeed, we found that mutants lacking the histone methyltransferase… CONTINUE READING