Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells.

@article{Kmita2002EvolutionaryCS,
  title={Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells.},
  author={Marie Kmita and Basile Tarchini and Denis Duboule and Yann H{\'e}rault},
  journal={Development},
  year={2002},
  volume={129 23},
  pages={5521-8}
}
Transcriptional regulation of vertebrate Hox genes involves enhancer sequences located either inside or outside the gene clusters. In the mouse Hoxd complex, for example, series of contiguous genes are coordinately controlled by regulatory sequences located at remote distances. However, in different cellular contexts, Hox genes may have to be insulated from undesirable external regulatory influences to prevent ectopic gene activation, a situation that would likely be detrimental to the… CONTINUE READING