Evolutionary conservation of regulated longevity assurance mechanisms

  title={Evolutionary conservation of regulated longevity assurance mechanisms},
  author={Joshua J. McElwee and Eugene F Schuster and Eric Blanc and Matthew D W Piper and James Harold Thomas and Dhaval S. Patel and Colin Selman and Dominic J. Withers and Janet M. Thornton and Linda Partridge and David Gems},
  journal={Genome Biology},
  pages={R132 - R132}
To what extent are the determinants of aging in animal species universal? Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) is an evolutionarily conserved (public) regulator of longevity; yet it remains unclear whether the genes and biochemical processes through which IIS acts on aging are public or private (that is, lineage specific). To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanying increased… CONTINUE READING

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Lack of peroxisomal catalase causes Genome Biology 2007, 8:R132 R132.16

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