Evolutionary conservation of histone modifications in mammals.

  title={Evolutionary conservation of histone modifications in mammals.},
  author={Yong H Woo and Wen-Hsiung Li},
  journal={Molecular biology and evolution},
  volume={29 7},
Histone modification is an important mechanism of gene regulation in eukaryotes. Why many histone modifications can be stably maintained in the midst of genetic and environmental changes is a fundamental question in evolutionary biology. We obtained genome-wide profiles of three histone marks, H3 lysine 4 tri-methylation (H3K4me3), H3 lysine 4 mono-methylation (H3K4me1), and H3 lysine 27 acetylation (H3K27ac), for several cell types from human and mouse. We identified histone modifications that… CONTINUE READING
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Gene clustering pattern, promoter architecture, and gene expression stability in eukaryotic genomes.

Proceedings of the National Academy of Sciences of the United States of America • 2011

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