Evolutionary conservation of histone modifications in mammals.

@article{Woo2012EvolutionaryCO,
  title={Evolutionary conservation of histone modifications in mammals.},
  author={Y. Woo and W. Li},
  journal={Molecular biology and evolution},
  year={2012},
  volume={29 7},
  pages={
          1757-67
        }
}
  • Y. Woo, W. Li
  • Published 2012
  • Biology, Medicine
  • Molecular biology and evolution
Histone modification is an important mechanism of gene regulation in eukaryotes. Why many histone modifications can be stably maintained in the midst of genetic and environmental changes is a fundamental question in evolutionary biology. We obtained genome-wide profiles of three histone marks, H3 lysine 4 tri-methylation (H3K4me3), H3 lysine 4 mono-methylation (H3K4me1), and H3 lysine 27 acetylation (H3K27ac), for several cell types from human and mouse. We identified histone modifications that… Expand
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