Evolutionary conservation of alternative activation of macrophages: structural and functional characterization of arginase 1 and 2 in carp (Cyprinus carpio L.).

@article{Joerink2006EvolutionaryCO,
  title={Evolutionary conservation of alternative activation of macrophages: structural and functional characterization of arginase 1 and 2 in carp (Cyprinus carpio L.).},
  author={Maaike Joerink and Huub F J Savelkoul and Geert Frits Wiegertjes},
  journal={Molecular immunology},
  year={2006},
  volume={43 8},
  pages={1116-28}
}
Classically activated macrophages (caMF) play an important role in type-I immune responses and alternatively activated macrophages (aaMF) function in type-II immune responses. While the classical activation of fish macrophages has been well described, the existence of aaMF has not yet been described for teleosts. Arginase is the characteristic enzyme in aaMF and two isoforms have been described for mammals. To study the presence of aaMF in a primitive vertebrate species we cloned arginase 1 and… CONTINUE READING