Evolutionary conservation of a microbody targeting signal that targets proteins to peroxisomes, glyoxysomes, and glycosomes

@article{Keller1991EvolutionaryCO,
  title={Evolutionary conservation of a microbody targeting signal that targets proteins to peroxisomes, glyoxysomes, and glycosomes},
  author={Gilbert A. Keller and Skaidrite K. Krisans and Stephen J. Gould and Jiirg M. Sommer and Chenqian Wang and Wolfgang Schliebs and Wolf-H. Kunau and Stuart Brody and Suresh Subramani},
  journal={The Journal of Cell Biology},
  year={1991},
  volume={114},
  pages={893 - 904}
}
Peroxisomes, glyoxysomes, glycosomes, and hydrogenosomes have each been classified as microbodies, i.e., subcellular organelles with an electron-dense matrix that is bound by a single membrane. We investigated whether these organelles might share a common evolutionary origin by asking if targeting signals used for translocation of proteins into these microbodies are related. A peroxisomal targeting signal (PTS) consisting of the COOH-terminal tripeptide serine-lysine-leucine-COOH has been… CONTINUE READING

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