Evolutionary conservation in protein folding kinetics.

  title={Evolutionary conservation in protein folding kinetics.},
  author={Kevin W. Plaxco and Susan Larson and Ingo Ruczinski and David S. Riddle and Edward C. Thayer and Brian J. Buchwitz and Alan R. Davidson and David Baker},
  journal={Journal of molecular biology},
  volume={298 2},
The sequence and structural conservation of folding transition states have been predicted on theoretical grounds. Using homologous sequence alignments of proteins previously characterized via coupled mutagenesis/kinetics studies, we tested these predictions experimentally. Only one of the six appropriately characterized proteins exhibits a statistically significant correlation between residues' roles in transition state structure and their evolutionary conservation. However, a significant… CONTINUE READING

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