Evolutionary consequences of DNA mismatch inhibited repair opportunity.

  title={Evolutionary consequences of DNA mismatch inhibited repair opportunity.},
  author={Wolfgang Stephan and Charles H. Langley},
  volume={132 2},
Double strand breaks (DSBs) are often repaired via homologous recombination. Recombinational repair processes are expected to be influenced by nucleotide heterozygosity through mismatch detection systems. Unrepaired DSBs have severe biological consequences and are often lethal. We show that natural selection due to inhibition of recombinational repair associated with polymorphisms could influence their molecular evolution. The main conclusions from this analysis are that, for increasing… CONTINUE READING