Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

@article{Makarova2019EvolutionaryCO,
  title={Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants},
  author={K. Makarova and Y. Wolf and J. Iranzo and Sergey A. Shmakov and O. Alkhnbashi and Stan J J Brouns and E. Charpentier and David R. Cheng and D. Haft and P. Horvath and S. Moineau and F. J. Mojica and D. Scott and S. Shah and V. {\vS}ik{\vs}nys and M. Terns and {\vC}. Venclovas and Malcolm F. White and A. Yakunin and W. Yan and Feng Zhang and R. Garrett and R. Backofen and J. van der Oost and R. Barrangou and E. Koonin},
  journal={Nature Reviews Microbiology},
  year={2019},
  volume={18},
  pages={67-83}
}
The number and diversity of known CRISPR–Cas systems have substantially increased in recent years. Here, we provide an updated evolutionary classification of CRISPR–Cas systems and cas genes, with an emphasis on the major developments that have occurred since the publication of the latest classification, in 2015. The new classification includes 2 classes, 6 types and 33 subtypes, compared with 5 types and 16 subtypes in 2015. A key development is the ongoing discovery of multiple, novel class 2… Expand
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