Evolutionary changes in the fungal carbamoyl-phosphate synthetase small subunit gene and its associated upstream open reading frame.

@article{Hood2007EvolutionaryCI,
  title={Evolutionary changes in the fungal carbamoyl-phosphate synthetase small subunit gene and its associated upstream open reading frame.},
  author={Heather M. Hood and Christina C. Spevak and Matthew S. Sachs},
  journal={Fungal genetics and biology : FG & B},
  year={2007},
  volume={44 2},
  pages={
          93-104
        }
}
The Neurospora crassa arg-2 and the Saccharomyces cerevisiae ortholog CPA1 encode the arginine-specific carbamoyl-phosphate synthetase (CPS-A) small subunit. Arginine decreases synthesis of this subunit through the action of a 5' upstream open reading frame in the mRNA that encodes a cis-regulatory element, the arginine attenuator peptide (AAP), which stalls ribosomes in response to arginine. We performed a comparative analysis of the genomic structure and predicted peptide sequence of the AAP… CONTINUE READING

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