Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E–eIF4G interactions

@inproceedings{Yoffe2009EvolutionaryCI,
  title={Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E–eIF4G interactions},
  author={Yael Yoffe and M{\'e}lissa L{\'e}ger and Alexandra Zinoviev and Joanna Żuberek and Edward Darzynkiewicz and Gerhard Wagner and Michal Shapira},
  booktitle={Nucleic acids research},
  year={2009}
}
Translation initiation in eukaryotes is mediated by assembly of the eIF4F complex over the m(7)GTP cap structure at the 5'-end of mRNAs. This requires an interaction between eIF4E and eIF4G, two eIF4F subunits. The Leishmania orthologs of eIF4E are structurally diverged from their higher eukaryote counterparts, since they have evolved to bind the unique trypanosomatid cap-4 structure. Here, we characterize a key eIF4G candidate from Leishmania parasites (LeishIF4G-3) that contains a conserved… CONTINUE READING

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