Evolutionary cell biology of chromosome segregation: insights from trypanosomes

  title={Evolutionary cell biology of chromosome segregation: insights from trypanosomes},
  author={Bungo Akiyoshi and Keith Gull},
  booktitle={Open biology},
Faithful transmission of genetic material is essential for the survival of all organisms. Eukaryotic chromosome segregation is driven by the kinetochore that assembles onto centromeric DNA to capture spindle microtubules and govern the movement of chromosomes. Its molecular mechanism has been actively studied in conventional model eukaryotes, such as yeasts, worms, flies and human. However, these organisms are closely related in the evolutionary time scale and it therefore remains unclear… CONTINUE READING
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