Evolutionary and functional relationships of colonization factor antigen i and other class 5 adhesive fimbriae of enterotoxigenic Escherichia coli.

@article{Anantha2004EvolutionaryAF,
  title={Evolutionary and functional relationships of colonization factor antigen i and other class 5 adhesive fimbriae of enterotoxigenic Escherichia coli.},
  author={Ravi P. Anantha and Annette L McVeigh and Lanfong H. Lee and Mary K. Agnew and Frederick J. Cassels and Dana S. Scott and Thomas S. Whittam and Stephen J. Savarino},
  journal={Infection and immunity},
  year={2004},
  volume={72 12},
  pages={
          7190-201
        }
}
Colonization factor antigen I (CFA/I) is the archetype of eight genetically related fimbriae of enterotoxigenic Escherichia coli (ETEC) designated class 5 fimbriae. Assembled by the alternate chaperone pathway, these organelles comprise a rigid stalk of polymerized major subunits and an apparently tip-localized minor adhesive subunit. We examined the evolutionary relationships of class 5-specific structural proteins and correlated these with functional properties. We sequenced the gene clusters… CONTINUE READING

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