Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos.

@article{Hentges2006EvolutionaryAF,
  title={Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos.},
  author={Pierre Hentges and Peter Ahnesorg and Robert S. Pitcher and Chris K Bruce and Boris Kysela and Andrew J Green and Julie Bianchi and Thomas E Wilson and Stephen P. Jackson and Aidan J. Doherty},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 49},
  pages={37517-26}
}
Non-homologous end-joining is a major pathway of DNA double-strand break repair in mammalian cells, deficiency in which confers radiosensitivity and immune deficiency at the whole organism level. A core protein complex comprising the Ku70/80 heterodimer together with a complex between DNA ligase IV and XRCC4 is conserved throughout eukaryotes and assembles at double-strand breaks to mediate ligation of broken DNA ends. In Saccharomyces cerevisiae an additional NHEJ protein, Nej1p, physically… CONTINUE READING