Evolutionary and biomedical insights from the rhesus macaque genome.


The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, rhesus monkeys are the most widely used nonhuman primate in basic and applied biomedical research. We determined the genome sequence of an Indian-origin Macaca mulatta female and compared the data with chimpanzees and humans to reveal the structure of ancestral primate genomes and to identify evidence for positive selection and lineage-specific expansions and contractions of gene families. A comparison of sequences from individual animals was used to investigate their underlying genetic diversity. The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species.

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@article{Gibbs2007EvolutionaryAB, title={Evolutionary and biomedical insights from the rhesus macaque genome.}, author={Richard A. Gibbs and Jeffrey Rogers and Michael G. Katze and Roger Eugene Bumgarner and George M. Weinstock and Elaine R. Mardis and Karin A. Remington and Robert Strausberg and J. Craig Venter and Richard K. Wilson and Mark A. Batzer and Carlos D. Bustamante and Evan E. Eichler and Matthew W. Hahn and Ross C. Hardison and Kateryna D. Makova and Webb Miller and Aleksandar Milosavljevic and Robert E Palermo and Adam C. Siepel and James M. Sikela and Tony Attaway and Stephanie Nicole Bell and Kelly E. Bernard and Christian Buhay and Mimi N Chandrabose and Marvin Diep Dao and Clay W Davis and Kimberly D. Delehaunty and Yan Ding and Huyen H. Dinh and Shannon P. Dugan-Rocha and Lucinda A. Fulton and Ramatu Ayiesha Gabisi and Toni T Garner and Jennifer L Godfrey and Alicia C. Hawes and Judith Hernandez and Sandra H. Hines and Michael E. Holder and Jennifer Hume and Shalini N. Jhangiani and Vandita Joshi and Ziad Mohid Khan and Ewen Kirkness and A. G. Cree and Richard G Fowler and Sandra L. Lee and Lora R. Lewis and Zhangwan Li and Yih-shin Liu and Stephanie Moore and Donna M. Muzny and Lynne V. Nazareth and Dinh Ngoc Ngo and Geoffrey O. Okwuonu and Grace H Pai and David Parker and Heidie A Paul and Cynthia M Pfannkoch and Craig S. Pohl and Yu-Hui C Rogers and San Juana Ruiz and Aniko Sabo and Jireh Santibanez and Brian W. Schneider and Scott M. Smith and Erica Sodergren and Amanda F Svatek and Teresa R . Utterback and Selina Vattathil and Wesley C. Warren and Courtney Sherell White and Asif T. Chinwalla and Yucheng Feng and Aaron L. Halpern and LaDeana W. Hillier and Xiaoqiu Huang and Pat Minx and Joanne O. Nelson and Kymberlie H. Pepin and Xiang Qin and Granger G. Sutton and Eli Venter and Brian Walenz and John W. Wallis and Kim Worley and Shiaw-Pyng Yang and Steven J. M. Jones and Marco A. Marra and Mariano Rocchi and Jacqueline E. Schein and Robert Baertsch and Laura Clarke and Mikl{\'o}s Cs{\"{u}r{\"{o}s and Jarret Glasscock and R. Alan Harris and Paul Havlak and Andrew R. Jackson and Huaiyang Jiang and Yue Liu and David N. Messina and Yufeng Shen and Henry Song and Todd Wylie and Lan Zhang and Ewan Birney and Kyudong Han and Miriam Konkel and Jungnam Lee and Arian Smit and Brygg Ullmer and Hui Wang and Jinchuan Xing and Richard Burhans and Ze Cheng and John E. Karro and Jian Ma and Brian J. Raney and Xinwei She and Michael J Cox and Jeffery P. Demuth and Laura J. Dumas and Sang-Gook Han and Janet Hopkins and Anis Karimpour-Fard and Young Hwa Kim and Jonathan R. Pollack and Tom{\'a}{\vs} Vinař and Charles Addo-Quaye and Jeremiah D. Degenhardt and Alexandra Denby and Melissa J. Hubisz and Amit R. Indap and Carolin Kosiol and Bruce T. Lahn and Heather A. Lawson and Alison R Marklein and Rasmus Nielsen and Eric J. Vallender and Andrew G. Clark and Betsy Ferguson and Ryan D. Hernandez and Kashif Hirani and Hildegard Kehrer-Sawatzki and Jessica Kolb and Shobha D. Patil and Ling-Ling Pu and Yanru Ren and Dennis J. Smith and David A. Wheeler and Ian N. Schenck and Edward V. Ball and Rui Chen and David N. Cooper and Belinda Giardine and Fan Hsu and W. James Kent and Arthur M. Lesk and David L. Nelson and William E O'brien and Kay Pr{\"{u}fer and Peter D. Stenson and James C. Wallace and Hui Ke and Xiao-ming Liu and Peng Wang and Andy Peng Xiang and Fan Yang and Galt P. Barber and David Haussler and Donna Karolchik and Andy D Kern and Robert M. Kuhn and Kayla E. Smith and Ann S Zwieg}, journal={Science}, year={2007}, volume={316 5822}, pages={222-34} }