Evolutionary analysis of the cystatin family in three Schistosoma species

  title={Evolutionary analysis of the cystatin family in three Schistosoma species},
  author={Yesid Cuesta-Astroz and Larissa Lopes Silva Scholte and Fabiano Sviatopolk-Mirsky Pais and Guilherme Oliveira and Laila A. Nahum},
  booktitle={Front. Genet.},
The cystatin family comprises cysteine protease inhibitors distributed in 3 subfamilies (I25A-C). Family members lacking cystatin activity are currently unclassified. Little is known about the evolution of Schistosoma cystatins, their physiological roles, and expression patterns in the parasite life cycle. The present study aimed to identify cystatin homologs in the predicted proteome of three Schistosoma species and other Platyhelminthes. We analyzed the amino acid sequence diversity focused… CONTINUE READING
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