Evolutionary analysis of genes of two pathways involved in placental malaria infection

@article{Sikora2008EvolutionaryAO,
  title={Evolutionary analysis of genes of two pathways involved in placental malaria infection},
  author={Martin Sikora and Anna Ferrer-Admetlla and Alfredo Mayor and Jaume Bertranpetit and Ferran Casals},
  journal={Human Genetics},
  year={2008},
  volume={123},
  pages={343-357}
}
Placental malaria is a special form of malaria that causes up to 200,000 maternal and infant deaths every year. Previous studies show that two receptor molecules, hyaluronic acid and chondroitin sulphate A, are mediating the adhesion of parasite-infected erythrocytes in the placenta of patients, which is believed to be a key step in the pathogenesis of the disease. In this study, we aimed at identifying sites of malaria-induced adaptation by scanning for signatures of natural selection in 24… CONTINUE READING