Evolutionary adaptation of plasmid-encoded enzymes for degrading nylon oligomers

@article{Okada1983EvolutionaryAO,
  title={Evolutionary adaptation of plasmid-encoded enzymes for degrading nylon oligomers},
  author={Hirosuke Okada and Seiji Negoro and Hiroyuki Kimura and Shunichi Nakamura},
  journal={Nature},
  year={1983},
  volume={306},
  pages={203-206}
}
  • Hirosuke Okada, Seiji Negoro, +1 author Shunichi Nakamura
  • Published 1983
  • Chemistry, Medicine
  • Nature
  • Flavobacterium sp. KI72 metabolizes 6-aminohexanoic acid cyclic dimer, a by-product of nylon manufacture1, through two newly evolved enzymes, 6-aminohexanoic acid cyclic dimer hydrolase (EI)2 and 6-aminohexanoic acid linear oligomer hydrolase (EII)3. These enzymes are active towards man-made compounds, the cyclic dimer and linear oligomers of 6-aminohexanoic acid respectively, but not towards any of the natural amide bonds tested2,3. The structural genes of EI (nylA) and EII (nylB) are encoded… CONTINUE READING

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