Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity

@inproceedings{Schnegge2017EvolutionaryAA,
  title={Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity},
  author={Anne-Marie Sch{\"o}negge and Jonathan Gallion and Louis-Philippe Picard and Angela D. Wilkins and Christian Le Gouill and Martin Audet and Wayne Stallaert and Martin J. Lohse and Marek Kimmel and Olivier Lichtarge and Michel Bouvier},
  booktitle={Nature Communications},
  year={2017}
}
Functional selectivity of G-protein-coupled receptors is believed to originate from ligand-specific conformations that activate only subsets of signaling effectors. In this study, to identify molecular motifs playing important roles in transducing ligand binding into distinct signaling responses, we combined in silico evolutionary lineage analysis and structure-guided site-directed mutagenesis with large-scale functional signaling characterization and non-negative matrix factorization… CONTINUE READING
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