Evolutionary Tuning of Protein Expression Levels of a Positively Autoregulated Two-Component System

@inproceedings{Gao2013EvolutionaryTO,
  title={Evolutionary Tuning of Protein Expression Levels of a Positively Autoregulated Two-Component System},
  author={Rong Gao and Ann M Stock},
  booktitle={PLoS genetics},
  year={2013}
}
Cellular adaptation relies on the development of proper regulatory schemes for accurate control of gene expression levels in response to environmental cues. Over- or under-expression can lead to diminished cell fitness due to increased costs or insufficient benefits. Positive autoregulation is a common regulatory scheme that controls protein expression levels and gives rise to essential features in diverse signaling systems, yet its roles in cell fitness are less understood. It remains largely… CONTINUE READING
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