Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1

@inproceedings{Fregoso2013EvolutionaryTO,
  title={Evolutionary Toggling of Vpx/Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1},
  author={Oliver I. Fregoso and Jinwoo Ahn and Chuanping Wang and Jennifer M Mehrens and Jacek Skowronski and Michael Emerman},
  booktitle={PLoS pathogens},
  year={2013}
}
SAMHD1 is a host restriction factor that blocks the ability of lentiviruses such as HIV-1 to undergo reverse transcription in myeloid cells and resting T-cells. This restriction is alleviated by expression of the lentiviral accessory proteins Vpx and Vpr (Vpx/Vpr), which target SAMHD1 for proteasome-mediated degradation. However, the precise determinants within SAMHD1 for recognition by Vpx/Vpr remain unclear. Here we show that evolution of Vpx/Vpr in primate lentiviruses has caused the… CONTINUE READING