Evolutionary Tinkering with Conserved Components of a Transcriptional Regulatory Network

@inproceedings{Lavoie2010EvolutionaryTW,
  title={Evolutionary Tinkering with Conserved Components of a Transcriptional Regulatory Network},
  author={Hugo Lavoie and Herv{\'e} Hogues and Jaideep Mallick and Adnane Sellam and Andr{\'e} M. Nantel and Malcolm Whiteway},
  booktitle={PLoS biology},
  year={2010}
}
Gene expression variation between species is a major contributor to phenotypic diversity, yet the underlying flexibility of transcriptional regulatory networks remains largely unexplored. Transcription of the ribosomal regulon is a critical task for all cells; in S. cerevisiae the transcription factors Rap1, Fhl1, Ifh1, and Hmo1 form a multi-subunit complex that controls ribosomal gene expression, while in C. albicans this regulation is under the control of Tbf1 and Cbf1. Here, we analyzed… CONTINUE READING

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