Evolutionary Rationale for Phages as Complements of Antibiotics.

  title={Evolutionary Rationale for Phages as Complements of Antibiotics.},
  author={Clara Torres-Barcel{\'o} and Michael E Hochberg},
  journal={Trends in microbiology},
  volume={24 4},
Antibiotic-resistant bacterial infections are a major concern to public health. Phage therapy has been proposed as a promising alternative to antibiotics, but an increasing number of studies suggest that both of these antimicrobial agents in combination are more effective in controlling pathogenic bacteria than either alone. We advocate the use of phages in combination with antibiotics and present the evolutionary basis for our claim. In addition, we identify compelling challenges for the… CONTINUE READING
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