Evolutionary Rates and Gene Dispensability Associate with Replication Timing in the Archaeon Sulfolobus islandicus

@inproceedings{Flynn2010EvolutionaryRA,
  title={Evolutionary Rates and Gene Dispensability Associate with Replication Timing in the Archaeon Sulfolobus islandicus},
  author={Kenneth M. Flynn and Samuel H. Vohr and Philip J. Hatcher and Vaughn S. Cooper},
  booktitle={Genome biology and evolution},
  year={2010}
}
In bacterial chromosomes, the position of a gene relative to the single origin of replication generally reflects its replication timing, how often it is expressed, and consequently, its rate of evolution. However, because some archaeal genomes contain multiple origins of replication, bias in gene dosage caused by delayed replication should be minimized and hence the substitution rate of genes should associate less with chromosome position. To test this hypothesis, six archaeal genomes from the… CONTINUE READING
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Biogeography of the Sulfolobus islandicus pan-genome.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 8 Excerpts
Highly Influenced

Transcription-coupled DNA repair in prokaryotes.

Progress in molecular biology and translational science • 2012

Chromosome replication dynamics in the archaeon Sulfolobus acidocaldarius.

Proceedings of the National Academy of Sciences of the United States of America • 2008

Whole-genome mutational biases in bacteria.

Proceedings of the National Academy of Sciences of the United States of America • 2008

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