Evolutionary Rate at the Molecular Level

@article{Kimura1968EvolutionaryRA,
  title={Evolutionary Rate at the Molecular Level},
  author={Motoo Kimura},
  journal={Nature},
  year={1968},
  volume={217},
  pages={624-626}
}
  • M. Kimura
  • Published 17 February 1968
  • Biology
  • Nature
Calculating the rate of evolution in terms of nucleotide substitutions seems to give a value so high that many of the mutations involved must be neutral ones. 

Parsimony in evolution, a natural fact.

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It is proposed that random genetic drift of neutral mutations in finite populations can account for observed protein polymorphisms.

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It is shown that, for one model of genetic evolution, the times at which mutations at nucleotide sites become fixed in a population tend to cluster together rather than behave as a Poisson process.

Silent nucleotide substitutions and the molecular evolutionary clock.

Half of the nucleotide substitutions during the evolutionary divergence of genes in animals, bacteria, and viruses are silent changes. These result from an inherent biochemical property of DNA and

Gene Duplication and Nucleotide Substitution in Evolution

There may be a great deal of gene duplication and also nonsense DNA in today's vertebrates.

Non-Darwinian Evolution: Consequences for Neutral Allelic Variation

A test is made of the hypothesis that there is a relationship between the rate of evolutionary change and the degree of neutral allelic variation in populations using data on haemoglobin variants in

Rates of molecular evolution: The hominoid slowdown

  • M. Goodman
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1985
It is proposed that early in phylogeny a large proportion of amino acid substitutions were selectively neutral, but that bursts of adaptive substitutions during major radiations of life so increased

Functional Organization of Genetic Material as a Product of Molecular Evolution

A sequence of events in which originally rare molecular mutants (DNA changes) spread into the species and two important classes of mutations are nucleotide (or amino-acid) replacement and gene duplication.

Mutational pressure as the main cause of molecular evolution and polymorphism

The advent of detailed studies on the evolution of individual molecules has cast into doubt some of the neo-Darwinian concepts of what determines evolutionary change. Much more emphasis must now be
...

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