Evolutionary Rate Covariation of Domain Families

  • Brandon Jernigan
  • Published 2018

Abstract

Evolutionary rate covariation (ERC) is a phylogenetic measure of the evolutionary relationship between pairs of proteins. As proteins evolve over time, their rate of evolution (dN/dS) may vary. ERC measures how closely the evolutionary rates of two proteins match over a phylogeny. Proteins known to interact directly or indirectly tend to have higher ERC… (More)

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