Evolutionary Origins of Pax6 Control of Crystallin Genes

@article{Cvekl2017EvolutionaryOO,
  title={Evolutionary Origins of Pax6 Control of Crystallin Genes},
  author={A. Cvekl and Yilin Zhao and R. Mcgreal and Qing Xie and X. Gu and D. Zheng},
  journal={Genome Biology and Evolution},
  year={2017},
  volume={9},
  pages={2075 - 2092}
}
Abstract The birth of novel genes, including their cell-specific transcriptional control, is a major source of evolutionary innovation. The lens-preferred proteins, crystallins (vertebrates: α- and β/γ-crystallins), provide a gateway to study eye evolution. Diversity of crystallins was thought to originate from convergent evolution through multiple, independent formation of Pax6/PaxB-binding sites within the promoters of genes able to act as crystallins. Here, we propose that αB-crystallin… Expand
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