Evolutionary Origins and Functions of the Stress Response System

  title={Evolutionary Origins and Functions of the Stress Response System},
  author={Randolph M. Nesse and S. Bhatnagar and Bruce J. Ellis},

Towards an Evolutionary Theory of Stress Responses.

Evolutionary Significance of the Neuroendocrine Stress Axis on Vertebrate Immunity and the Influence of the Microbiome on Early-Life Stress Regulation and Health Outcomes

The evolutionary significance of the stress-axis system for health maintenance is explored and recent findings that connect early-life microbiome disturbances to alterations in the development of stress response networks are reviewed.

Convergence on reduced stress behavior in the Mexican blind cavefish.

Social stress models in rodents

Understanding the role of the social environment in the development of stress related diseases requires a more fundamental understanding of stress. Stress includes not only the stimulus and the

Stress Hormones, Physiology, and Behavior

This chapter reviews pertinent topics and research within the social neuroendocrine study of stress, including acute versus chronic stress, and how stress influences social behavior and status, and includes suggestions for future directions within this research area.

Social stress models in rodents: Towards enhanced validity

Significance of DopEcR, a G-protein coupled dopamine/ecdysteroid receptor, in physiological and behavioral response to stressors

Findings provide corroborating evidence that DopEcR plays vital roles in responses to various stressors, including heat, starvation, alcohol, courtship rejection, and repeated neuronal stimulation in Drosophila.

“Landscape of Stress” for Sheep Owners in the Swedish Wolf Region

Farmers who keep livestock in large carnivore areas are exposed to threat of predation directly impacting on finances and workload as well as the associated psychological stress indirectly impacting



The stress response systems: Universality and adaptive individual differences


This study implicates multiple life‐cycle stages in the response to selection for the stress resistance of only one stage, and shows that patterns of genetic correlation may prove misleading unless multiple pleiotropic interconnections are resolved.

The Adaptive Calibration Model of stress responsivity

Beyond Allostatic Load The Stress Response System as a Mechanism of Conditional Adaptation

THE STRESS RESPONSE SYSTEM (SRS) has a central role in orchestrating physical and psychosocial development of both humans and nonhuman species (Ellis, Jackson, & Boyce, 2006; Korte, Koolhaas,

Beyond allostatic load: Rethinking the role of stress in regulating human development

The adaptive calibration model is proposed, which proposes that consideration of biological fitness trade-offs, as delineated by life history theory, is needed to more fully explain the complex relations between developmental exposures to stress, stress responsivity, behavioral strategies, and health.

Physiological functions of glucocorticoids in stress and their relation to pharmacological actions.

It is proposed that stress-induced increases in glucocorticoid levels protect not against the source of stress itself but rather against the body's normal reactions to stress, preventing those reactions from overshooting and themselves threatening homeostasis.

Maternal Programming of Individual Differences in Defensive Responses in the Rat

The results of a series of studies showing that variations in mother‐pup interactions program the development of individual differences in behavioral and endocrine stress responses in the rat suggest an epigenetic process whereby the experience of the mother alters the nature of the parent‐offspring interactions and thus the phenotype of the offspring.