Evolutionary Modeling of Rate Shifts Reveals Specificity Determinants in HIV-1 Subtypes

@article{Penn2008EvolutionaryMO,
  title={Evolutionary Modeling of Rate Shifts Reveals Specificity Determinants in HIV-1 Subtypes},
  author={Osnat Penn and Adi Stern and Nimrod D. Rubinstein and Julien Y Dutheil and Eran Bacharach and Nicolas Galtier and Tal Pupko},
  journal={PLoS Computational Biology},
  year={2008},
  volume={4},
  pages={S63 - S68}
}
A hallmark of the human immunodeficiency virus 1 (HIV-1) is its rapid rate of evolution within and among its various subtypes. Two complementary hypotheses are suggested to explain the sequence variability among HIV-1 subtypes. The first suggests that the functional constraints at each site remain the same across all subtypes, and the differences among subtypes are a direct reflection of random substitutions, which have occurred during the time elapsed since their divergence. The alternative… CONTINUE READING

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