Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?

@article{Longo2003EvolutionaryMF,
  title={Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?},
  author={Valter D. Longo and Caleb E. Finch},
  journal={Science},
  year={2003},
  volume={299},
  pages={1342 - 1346}
}
Restriction of the number of calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation without irreversible side effects. In organisms ranging from yeast to mice, mutations in glucose or IGF-I–like signaling pathways extend life-span but also cause glycogen or fat accumulation and dwarfism. This information suggests a… 

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