Evolutionary Insights into RNA trans-Splicing in Vertebrates.

  title={Evolutionary Insights into RNA trans-Splicing in Vertebrates.},
  author={Quan Lei and C Li and Zhixiang Zuo and Chunhua Huang and Hanhua Cheng and Rongjia Zhou},
  journal={Genome biology and evolution},
  volume={8 3},
Pre-RNA splicing is an essential step in generating mature mRNA. RNA trans-splicing combines two separate pre-mRNA molecules to form a chimeric non-co-linear RNA, which may exert a function distinct from its original molecules. Trans-spliced RNAs may encode novel proteins or serve as noncoding or regulatory RNAs. These novel RNAs not only increase the complexity of the proteome but also provide new regulatory mechanisms for gene expression. An increasing amount of evidence indicates that trans… CONTINUE READING
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