Evolutionary History of the Clostridium difficile Pathogenicity Locus

@inproceedings{Dingle2014EvolutionaryHO,
  title={Evolutionary History of the Clostridium difficile Pathogenicity Locus},
  author={Kate E. Dingle and Briony Elliott and E. M. Robinson and David B. Griffiths and David W. Eyre and Nicole Stoesser and Alison Vaughan and Tanya Golubchik and Warren N. Fawley and Mark Wilcox and Timothy E. A Peto and A. Sarah Walker and Thomas V Riley and Derrick W. Crook and Xavier Didelot},
  booktitle={Genome biology and evolution},
  year={2014}
}
The symptoms of Clostridium difficile infection are caused by toxins expressed from its 19 kb pathogenicity locus (PaLoc). Stable integration of the PaLoc is suggested by its single chromosomal location and the clade specificity of its different genetic variants. However, the PaLoc is variably present, even among closely related strains, and thus resembles a mobile genetic element. Our aim was to explain these apparently conflicting observations by reconstructing the evolutionary history of the… CONTINUE READING

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