Evolutionary Dynamics of Abundant Stop Codon Readthrough

@inproceedings{Jungreis2016EvolutionaryDO,
  title={Evolutionary Dynamics of Abundant Stop Codon Readthrough},
  author={Irwin Jungreis and C. S. Patrick Chan and Robert M. Waterhouse and Gabriel Fields and Michael F. Lin and Manolis Kellis},
  booktitle={Molecular biology and evolution},
  year={2016}
}
Translational stop codon readthrough emerged as a major regulatory mechanism affecting hundreds of genes in animal genomes, based on recent comparative genomics and ribosomal profiling evidence, but its evolutionary properties remain unknown. Here, we leverage comparative genomic evidence across 21 Anopheles mosquitoes to systematically annotate readthrough genes in the malaria vector Anopheles gambiae, and to provide the first study of abundant readthrough evolution, by comparison with 20… CONTINUE READING

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