Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters

  title={Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters},
  author={Gerold Schmitt-Ulms and S. P. Ehsani and Joel C. Watts and David Westaway and Holger Wille},
  booktitle={PloS one},
In the more than twenty years since its discovery, both the phylogenetic origin and cellular function of the prion protein (PrP) have remained enigmatic. Insights into a possible function of PrP may be obtained through the characterization of its molecular neighborhood in cells. Quantitative interactome data demonstrated the spatial proximity of two metal ion transporters of the ZIP family, ZIP6 and ZIP10, to mammalian prion proteins in vivo. A subsequent bioinformatic analysis revealed the… CONTINUE READING
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