Evolutionary Consideration on 5-aminolevulinate Synthase in Nature

  title={Evolutionary Consideration on 5-aminolevulinate Synthase in Nature},
  author={T. Oh-hama},
  journal={Origins of life and evolution of the biosphere},
5-Aminolevulinic acid (ALA), a universal precursor of tetrapyrrole compounds can be synthesized by two pathways: the C5 (glutamate) pathway and ALA synthase. From the phylogenetic distribution it is shown that distribution of ALA synthase is restricted to the α subclass of purple bacteria in prokaryotes, and further distributed to mitochondria of eukaryotes. The monophyletic origin of bacterial and eukaryotic ALA synthase is shown by sequence analysis of the enzyme. Evolution of ALA synthase in… CONTINUE READING
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